6,957 research outputs found

    Anticipating a New Golden Age

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    The standard model of fundamental interactions is remarkably successful, but it leaves an unfinished agenda. Several major questions seem ripe for exploration in the near future. I anticipate that the coming decade will be a Golden Age of discovery in fundamental physics.Comment: 25 pages, 15 figures. Version 3: Added references, caption to Figure 14 correcte

    Advantages and Distinguishing Features of Focus Point Supersymmetry

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    Diverse experimental constraints now motivate models of supersymmetry breaking in which some superpartners have masses well above the weak scale. Three alternatives are focus point supersymmetry and inverted hierarchy models, which embody a naturalness constraint, and the more recent framework of split supersymmetry, which relaxes that constraint. Many aspects of their phenomenology are very similar. They can be distinguished, however, through detailed study of superoblique parameters, the Higgs potential and other observables.Comment: 9 pages, published versio

    Algebraic Approach to Physical-Layer Network Coding

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    The problem of designing physical-layer network coding (PNC) schemes via nested lattices is considered. Building on the compute-and-forward (C&F) relaying strategy of Nazer and Gastpar, who demonstrated its asymptotic gain using information-theoretic tools, an algebraic approach is taken to show its potential in practical, non-asymptotic, settings. A general framework is developed for studying nested-lattice-based PNC schemes---called lattice network coding (LNC) schemes for short---by making a direct connection between C&F and module theory. In particular, a generic LNC scheme is presented that makes no assumptions on the underlying nested lattice code. C&F is re-interpreted in this framework, and several generalized constructions of LNC schemes are given. The generic LNC scheme naturally leads to a linear network coding channel over modules, based on which non-coherent network coding can be achieved. Next, performance/complexity tradeoffs of LNC schemes are studied, with a particular focus on hypercube-shaped LNC schemes. The error probability of this class of LNC schemes is largely determined by the minimum inter-coset distances of the underlying nested lattice code. Several illustrative hypercube-shaped LNC schemes are designed based on Construction A and D, showing that nominal coding gains of 3 to 7.5 dB can be obtained with reasonable decoding complexity. Finally, the possibility of decoding multiple linear combinations is considered and related to the shortest independent vectors problem. A notion of dominant solutions is developed together with a suitable lattice-reduction-based algorithm.Comment: Submitted to IEEE Transactions on Information Theory, July 21, 2011. Revised version submitted Sept. 17, 2012. Final version submitted July 3, 201

    Communication over Finite-Chain-Ring Matrix Channels

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    Though network coding is traditionally performed over finite fields, recent work on nested-lattice-based network coding suggests that, by allowing network coding over certain finite rings, more efficient physical-layer network coding schemes can be constructed. This paper considers the problem of communication over a finite-ring matrix channel Y=AX+BEY = AX + BE, where XX is the channel input, YY is the channel output, EE is random error, and AA and BB are random transfer matrices. Tight capacity results are obtained and simple polynomial-complexity capacity-achieving coding schemes are provided under the assumption that AA is uniform over all full-rank matrices and BEBE is uniform over all rank-tt matrices, extending the work of Silva, Kschischang and K\"{o}tter (2010), who handled the case of finite fields. This extension is based on several new results, which may be of independent interest, that generalize concepts and methods from matrices over finite fields to matrices over finite chain rings.Comment: Submitted to IEEE Transactions on Information Theory, April 2013. Revised version submitted in Feb. 2014. Final version submitted in June 201

    Discovery of mHz X-ray Oscillations in a Transient Ultraluminous X-ray Source in M82

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    We report the discovery of X-ray quasi-periodic oscillations (QPOs) at frequencies of 3-4 mHz from a transient ultraluminous X-ray source (ULX) X42.3+59 in M82. The QPOs are strong and broad and appear with weak or absent red noise, and are detected only in Chandra observations when the source is brighter than 10^40 ergs/s. The QPO behavior is similar to the type A-I QPOs found in XTE J1550-564, which is a subclass of low frequency QPOs with properties in between type A and B. Therefore, we identify the QPOs in X42.3+59 as of type A or B, and rule out the possibility of type C. With this identification, the mass of the black hole in X42.3+59 can be inferred as in the range of 12,000-43,000 solar masses by scaling the QPO frequency to that of the type A/B QPOs in stellar mass black holes. Cool disk emission is detected in one Chandra observation, and the disk inner radius suggests a similar black hole mass range. Black holes of such a high mass are able to produce an energy output in a manner similar to X42.3+59 by accreting from the interstellar medium directly.Comment: 5 pages, 1 figure, accepted for publication in The Astrophysical Journal Letter

    Performance of Cpred/Cobs concentration ratios as a metric reflecting adherence to antidepressant drug therapy

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    Background: Nonadherence is very common among subjects undergoing pharmacotherapy for schizophrenia and depression. This study aimed to evaluate the performance of the ratio of the nonlinear mixed effects pharmacokinetic model predicted concentration to observed drug concentration (ratio of population predicted to observed concentration (Cpred/Cobs) and ratio of individual predicted to observed concentration (Cipred/Cobs) as a measure of erratic drug exposure, driven primarily by variable execution of the dosage regimen and unknown true dosage history. Methods: Modeling and simulation approaches in conjunction with dosage history information from the Medication Event Monitoring System (MEMS, provided by the "Depression: The search for treatment relevant phenotypes" study), was applied to evaluate the consistency of exposure via simulation studies with scenarios representing a long half-life drug (escitalopram). Adherence rates were calculated based on the percentage of the prescribed doses actually taken correctly during the treatment window of interest. The association between Cpred/Cobs, Cipred/Cobs ratio, and adherence rate was evaluated under various assumptions of known dosing history. Results: Simulations for those scenarios representing a known dosing history were generated from historical MEMS data. Simulations of a long half-life drug exhibited a trend for overprediction of concentrations in patients with a low percentage of doses taken and underprediction of concentrations in patients taking more than their prescribed number of doses. Overall, the ratios did not predict adherence well, except when the true adherence rates were extremely high (greater than 100% of prescribed doses) or extremely low (complete nonadherence). In general, the Cipred/Cobs ratio was a better predictor of adherence rate than the Cpred/Cobs ratio. Correct predictions of extreme (high, low) 7-day adherence rates using Cipred/Cobs were 73.8% and 64.0%. Conclusion: This simulation study demonstrated the limitations of the Cpred/obs and Cipred/obs ratios as metrics for actual dosage intake history, and identified that use of MEMS dosing history monitoring combined with sparse pharmacokinetic sampling is a more reliable approach. © 2011 Feng et al

    Quantum Spin Liquid with Even Ising Gauge Field Structure on Kagome Lattice

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    Employing large-scale quantum Monte Carlo simulations, we study the extended XXZXXZ model on the kagome lattice. A Z2\mathbb Z_2 quantum spin liquid phase with effective even Ising gauge field structure emerges from the delicate balance among three symmetry-breaking phases including stripe solid, staggered solid and ferromagnet. This Z2\mathbb{Z}_2 spin liquid is stabilized by an extended interaction related to the Rokhsar-Kivelson potential in the quantum dimer model limit. The phase transitions from the staggered solid to a spin liquid or ferromagnet are found to be first order and so is the transition between the stripe solid and ferromagnet. However, the transition between a spin liquid and ferromagnet is found to be continuous and belongs to the 3D XY∗XY^* universality class associated with the condensation of spinons. The transition between a spin liquid and stripe solid appears to be continuous and associated with the condensation of visons.Comment: 7 pages, 8 figure
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